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KMID : 0380620120440020148
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Korean Journal of Food Science and Technology
2012 Volume.44 No. 2 p.148 ~ p.154
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Monitoring of Forbidden Medicines as Adulterants in Dietary Supplements Marketed Online by HPLC and ESI-tandom Mass Spectrometry
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Lee Yong-Chul
Kim Bog-Soon
Yun En-Sun
Kim Sung-Dan
Chang Min-Su
Park Young-Ae
Shin Young
Jung Sun-Ok
Lee Jae-In
Chae Young-Zoo
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Abstract
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It was carried out to detect anti-impotence drug-like compounds, sibutramine and their analogues in dietary supplements, which are doubtful whether they include illegal compounds. A total of 51 food products were bought online and have been investigated. The separation was achieved on a C18 column, with the mobile phase made up of water (5 mM sodium hexanesulfonate and 0.1% phosphoric acid) and 95% acetonitrile, at a flow rate of 1.2 mL/min with gradient elution using by HPLC-DAD. The UV signals were monitored at 220 nm and 291 nm. LC-ESI-tandom MS was utilized to confirm that detected compounds in samples are the same as the reference materials. Two nutrient supplement foods and ginseng products were found to contain 1.3-82.1 mg of sildenafil, dimethylthiolsildenafil and pseudovardenafil per serving size. In addition, two other processed products were detected to contain 1.7 and 2.2 mg of didesmethylsibutramine, derived from sibutramine per serving size.
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KEYWORD
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anti-impotence drug, sildenafil, sibutramine, LC-ESI-MS
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